A case of Seip-Lawrence syndrome with acanthosis nigricans.

Seip-Lawrence syndrome is the total lipodystrophy which unites the con genital and acquired forms of the disease under one eponym.1) In 1946, Lawrence2) originally characterized this syndrome by absence of subcutaneous fat tissue, insulin-resistant diabetes unassociated with ketosis, hepatic cirrhosis, hypermeta bolism under the presence of euthyroidism, and hyperlipemia. Since then we only recognized about twenty four additional cases reporting this syndrome: four in Japan 3141 and about twenty in foreign countries. Among them, fourteen cases were attended with acanthosis nigricans. In this paper we present a case of this syndrome and discuss on some comments about it.